The game uses the features of the Wii Remote and Nunchuck in place of the stylus-based gameplay of the DS game. The gameplay in Trauma Center: Second Opinion is very similar to it's predecessor Trauma Center: Under the Knife. New "Z-Missions" were added as well, along with a side narrative featuring Nozomi Weaver, a new character that like original protagonist Derek Stiles has the powers of the Healing Touch. The existing characters were all given a facelift using a new art style.
A remake of Atlus's DS title Trauma Center: Under the Knife, the game adapts the original game's stylus-based gameplay to work with the Wii Remote and Nunchuk. Trauma Center: Second Opinion was released on November 19th, 2006 as a Wii launch title.
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